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Childhood socioeconomic status and longitudinal patterns of alcohol problems: Variation across etiological pathways in genetic risk.
Barr, Peter
Silberg, Judy Dick, Danielle M Maes, Hermine H
Silberg, Judy
Dick, Danielle M
Maes, Hermine H
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Social science & medicine (1982)
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2018-05-14
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Publication Volume
209
Publication Issue
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51
Publication End
58
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nihms969657.pdf
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Abstract
Childhood socioeconomic status (SES) is an important aspect of early life environment associated with later life health/health behaviors, including alcohol misuse. However, alcohol misuse is modestly heritable and involves differing etiological pathways. Externalizing disorders show significant genetic overlap with substance use, suggesting an impulsivity pathway to alcohol misuse. Alcohol misuse also overlaps with internalizing disorders, suggesting alcohol is used to cope. These differing pathways could lead to different patterns over time and/or differential susceptibility to environmental conditions, such as childhood SES. We examine whether: 1) genetic risk for externalizing and internalizing disorders influence trajectories of alcohol problems across adolescence to adulthood, 2) childhood SES alters genetic risk these disorders on trajectories of alcohol problems, and 3) these patterns are consistent across sex. We find modest evidence of gene-environment interaction. Higher childhood SES increases the risk of alcohol problems in late adolescence/early adulthood, while lower childhood SES increases the risk of alcohol problems in later adulthood, but only among males at greater genetic risk of externalizing disorders. Females from lower SES families with higher genetic risk of internalizing or externalizing disorders have greater risk of developing alcohol problems.
Citation
Barr PB, Silberg J, Dick DM, Maes HH. Childhood socioeconomic status and longitudinal patterns of alcohol problems: Variation across etiological pathways in genetic risk. Soc Sci Med. 2018 Jul;209:51-58. doi: 10.1016/j.socscimed.2018.05.027. Epub 2018 May 14. PMID: 29793164; PMCID: PMC5997543.