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Continuity of Genetic Risk for Aggressive Behavior Across the Life-Course.
van der Laan, Camiel M; Morosoli-GarcĆa, JosĆ© J; van de Weijer, Steve G A; Colodro-Conde, LucĆa; Lupton, Michelle K; Mitchell, Brittany L; McAloney, Kerrie; Parker, Richard; Burns, Jane M; Hickie, Ian B; Pool, RenĆ©; Hottenga, Jouke-Jan; Martin, Nicholas G; Medland, Sarah E; Nivard, Michel G; Boomsma, Dorret I
Journal Title
Behavior genetics
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Publication Date
2021-08-14
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Publication Volume
51
Publication Issue
5
Publication Begin
592
Publication End
606
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s10519-021-10076-6.pdf
Adobe PDF, 911.34 KB
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Abstract
We test whether genetic influences that explain individual differences in aggression in early life also explain individual differences across the life-course. In two cohorts from The Netherlands (Nā=ā13,471) and Australia (Nā=ā5628), polygenic scores (PGSs) were computed based on a genome-wide meta-analysis of childhood/adolescence aggression. In a novel analytic approach, we ran a mixed effects model for each age (Netherlands: 12-70 years, Australia: 16-73 years), with observations at the focus age weighted as 1, and decaying weights for ages further away. We call this approach a 'rolling weights' model. In The Netherlands, the estimated effect of the PGS was relatively similar from age 12 to age 41, and decreased from age 41-70. In Australia, there was a peak in the effect of the PGS around age 40 years. These results are a first indication from a molecular genetics perspective that genetic influences on aggressive behavior that are expressed in childhood continue to play a role later in life.
Citation
van der Laan CM, Morosoli-GarcĆa JJ, van de Weijer SGA, Colodro-Conde L; ACTION Consortium; Lupton MK, Mitchell BL, McAloney K, Parker R, Burns JM, Hickie IB, Pool R, Hottenga JJ, Martin NG, Medland SE, Nivard MG, Boomsma DI. Continuity of Genetic Risk for Aggressive Behavior Across the Life-Course. Behav Genet. 2021 Sep;51(5):592-606. doi: 10.1007/s10519-021-10076-6. Epub 2021 Aug 14. PMID: 34390460; PMCID: PMC8390412.