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The soymilk diet: A previously unknown etiology of acute pancreatitis.
Journal Title
The American journal of emergency medicine
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Publication Date
2021-01-27
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46
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Publication Begin
798.e5
Publication End
798.e6
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Abstract
We present a case of daily, large ingestions of soymilk that likely led to acute pancreatitis. Soybean contains trypsin inhibitor that when ingested will reduce the activity of trypsin in the intestine. A decrease in intestinal proteolytic activity removes the negative feedback on the pancreatic acinar cells, leading to an inappropriate increase in intrapancreatic trypsin secretion. When trypsin activation exceeds the capacity of pancreatic secretory trypsin inhibitor, the subsequent cascade of events can lead to acute pancreatitis.
Citation
deSouza IS, Lipsitt A. The soymilk diet: A previously unknown etiology of acute pancreatitis. Am J Emerg Med. 2021 Aug;46:798.e5-798.e6. doi: 10.1016/j.ajem.2021.01.055. Epub 2021 Jan 27. PMID: 33546956.