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In vitro activity of a new antibiotic, NVP-PDF386 (VRC4887), against Chlamydia pneumoniae.
Journal Title
Antimicrobial agents and chemotherapy
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2003-04
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47
Publication Issue
4
Publication Begin
1447
Publication End
8
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Abstract
The in vitro activity of NVP-PDF386 (VRC4887), a novel new peptide deformylase inhibitor, and those of levofloxacin and clarithromycin were tested against 21 isolates of Chlamydia pneumoniae. The MIC at which 90% of the isolates were inhibited and the minimal bactericidal concentration at which 90% of the isolates were killed by NVP-PDF386 for all isolates of C. pneumoniae were 0.008 micro g/ml (range, 0.008 to 0.015 micro g/ml) compared to 0.25 and 0.06 micro g/ml for levofloxacin and clarithromycin, respectively.
Citation
Roblin PM, Hammerschlag MR. In vitro activity of a new antibiotic, NVP-PDF386 (VRC4887), against Chlamydia pneumoniae. Antimicrob Agents Chemother. 2003 Apr;47(4):1447-8. doi: 10.1128/AAC.47.4.1447-1448.2003. PMID: 12654690; PMCID: PMC152502.