Loading...
When Gastrin Goes Awry: A Review of Normal Function and Role of Gastrin in Zollinger-Ellison Syndrome
LaTourette, Leigha Cross, Janel Brabetz, Barbara
LaTourette, Leigha
Cross, Janel
Brabetz, Barbara
Citations
Altmetric:
Journal Title
Keywords
Readers/Advisors
Journal Title
Term and Year
Publication Date
2018-05
Book Title
Publication Volume
Publication Issue
Publication Begin
Publication End
Number of pages
Collections
Files
Loading...
Gastrin.pdf
Adobe PDF, 2.23 MB
Request File
Research Projects
Organizational Units
Journal Issue
Abstract
Citation
DOI
Description
Gastrin is a digestive hormone that acts on the neuroendocrine and parietal cells of the gastrointestinal tract to ultimately secrete gastric acid. Gastrin secretion begins even before food is consumed, as the mere anticipation of a meal can lead to a series of events ending in the creation of the gastric acid needed to breakdown foods. Not only does Gastrin support the digestion of foods, but it also stimulates growth, secretion, blood flow, and acts as a defense mechanism against bacteria in the gastrointestinal system. When the production of Gastrin becomes overt, major consequences like that of Zollinger Ellison Syndrome (ZES). ZES is an extremely rare disease occurring in people between the ages of 30-60.4 ZES is related to the uncontrolled secretion of gastrin due to the presence of certain pancreatic or duodenal tumors. The tumor stimulates the acid-secreting cells of the stomach to maximal activity, with consequent gastrointestinal mucosal ulceration.