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Genetic and culture-based approaches for detecting macrolide resistance in Chlamydia pneumoniae.
Journal Title
Antimicrobial agents and chemotherapy
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2004-09
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48
Publication Issue
9
Publication Begin
3586
Publication End
90
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Abstract
Three clinical Chlamydia pneumoniae isolates for which the MIC of azithromycin increased after treatment were investigated for genetic evidence of macrolide resistance. Attempts to induce antibiotic resistance in vitro were made. No genetic mechanism was identified for the phenotypic change in these C. pneumoniae isolates. No macrolide resistance was obtained in vitro.
Citation
Riska PF, Kutlin A, Ajiboye P, Cua A, Roblin PM, Hammerschlag MR. Genetic and culture-based approaches for detecting macrolide resistance in Chlamydia pneumoniae. Antimicrob Agents Chemother. 2004 Sep;48(9):3586-90. doi: 10.1128/AAC.48.9.3586-3590.2004. PMID: 15328134; PMCID: PMC514725.