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Journal Title
Communicative & Integrative Biology
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2015-04-15
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8
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2
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e1017163
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Abstract
Widely thought to be a housekeeping process, the regulation and synthesis of rRNA emerges as a potentially central mechanism for the maintenance of synaptic plasticity and memory. We have recently shown that an essential component of late-phase synaptic plasticity is rRNA biosynthesis - the rate-limiting step in the production of new ribosomes. We hypothesize that a particular population of ribosomes is generated upon learning-associated neural activity to alter the rate of synthesis of plasticity factors at tagged synapses that will support the maintenance of synaptic plasticity and memory.
Citation
Hernández AI, Alarcon JM, Allen KD. New ribosomes for new memories? Commun Integr Biol. 2015 Apr 15;8(2):e1017163. doi: 10.1080/19420889.2015.1017163. Erratum for: Addendum to: Allen KD, Gourov AV, Harte C, Gao P, Lee C, Sylvain D, et al. Nucleolar integrity is required for the maintenance of long-term synaptic plasticity. PLoS One 2014; 9:e104364. PMID: 26479998; PMCID: PMC4594611.