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Journal Title
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases
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1996
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Publication Volume
1 Suppl 1
Publication Issue
Publication Begin
S3
Publication End
S8
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PIIS1198743X14652241.pdf
Adobe PDF, 1.81 MB
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Abstract
Diagnosis of infection with Chlamydia pneumoniae is difficult and the optimal diagnostic procedure has yet to be established. C. pneumoniae is more difficult to isolate in tissue culture than C. trachomatis. Attention must be paid to the site from which the specimen is taken, and all specimens should be processed within 24 h or stored at 4 C. Serologic diagnosis largely depends on microimmunofluorescence testing which, despite proposed criteria, still has a large subjective component. Serology has limitations in terms of both sensitivity and specificity and antibodies may be difficult to detect in individuals with positive C. pneumoniae cultures. Non-culture methods include enzyme immunoassays, fluorescent-antibody techniques and DNA probes. The most promising appears to be PCR. Co-infection of C. pneumoniae and other respiratory organisms seem to be common.
Citation
Hammerschlag MR. Diagnostic methods for intracellular pathogens. Clin Microbiol Infect. 1996 Mar;1 Suppl 1:S3-S8. doi: 10.1111/j.1469-0691.1996.tb00582.x. PMID: 11866786.