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Developmental lead exposure alters rodent maternal pup retrieval disrupting adolescent social play
Bonnitto, Jalen, R. Hameed, Nimra Skeen, Jourvonn Dacius, Teddy Barrera, Eddy Rubi, Samantha Khairi, Eric Iqbal, Asma Lynch, Kirsten Ahmed, Isra
Bonnitto, Jalen, R.
Hameed, Nimra
Skeen, Jourvonn
Dacius, Teddy
Barrera, Eddy
Rubi, Samantha
Khairi, Eric
Iqbal, Asma
Lynch, Kirsten
Ahmed, Isra
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2018-04
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Developmental lead (Pb) exposure remains a valuable neurotoxicant rodent model of human environmentally induced cognitive disability, yet less is known about Pb-exposure on maternal pup care and its relationship to adolescent social-emotional behaviors such as social-play. Here we examined two developmental time-periods of Pb-exposure (i.e., Perinatal [PERI; pairing to day 22] and Postnatal [EPN; From Birth to day 22]), as well as the dose-response effects of Pb (i.e., 25 ppm, 150 ppm, and 1,000 ppm) administered through the drinking water. Maternal pup retrieval behaviors (i.e., latency across postnatal day (PND) 2-7) were correlated with adolescent social- play behaviors (i.e., attacks, pins, defenses, counters, and climbs) and compared against age- matched Control rats. The results showed that PERI and EPN maternal Pb-exposure increased pup * retrieval latencies from PND 5-7 when compared to Control rats. Additionally as a function of Pb- i dose, PERI maternal pup retrieval latencies increased from PNDs 5-7 with little within Pb dose- l effects. Adolescent social-play behaviors showed a sex-based increased difference in female rats engaging in more attacks, defenses, pins, counters, and climbs than males. PERI 150 ppm treated adolescent rats showed reduced female social-play behaviors, but were elevated in males. At PERI 1,000 ppm exposures, female social-play behaviors were similar to PBRI 150 ppm female rats, but interestingly males exhibited a 2- to 3-fold increase in social-play behaviors. These data suggest that environmental Pb-exposure may negatively influence maternal social care behaviors, thereby altering the natural trajectory of developmental social-emotional behaviors that emerge in adolescence with lifespan impacts. (SUNY-OW Faculty Development Grant).
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Student research from multiple departments examining the effects of lead exposure on rodent maternal pup retrieval and how it disrupts adolescent social-play.