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The potential utility of integrated reflectance confocal microscopy-optical coherence tomography for guiding triage and therapy of basal cell carcinomas.
Iftimia, Nicusor Sahu, Aditi Cordova, Miguel Maguluri, Gopi Gill, Melissa Alessi-Fox, Christi Gonzalez, Salvador Navarrete-Dechent, Cristian Marghoob, Ashfaq Chen, Chih-Shan J
Iftimia, Nicusor
Sahu, Aditi
Cordova, Miguel
Maguluri, Gopi
Gill, Melissa
Alessi-Fox, Christi
Gonzalez, Salvador
Navarrete-Dechent, Cristian
Marghoob, Ashfaq
Chen, Chih-Shan J
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Journal Title
Journal of Cancer
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Publication Date
2020-08-18
Type
Book Title
Publication Volume
11
Publication Issue
20
Publication Begin
6019
Publication End
6024
Number of pages
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v11p6019.pdf
Adobe PDF, 1.92 MB
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Abstract
The increasing rate of incidence and prevalence of basal cell carcinomas (BCCs) worldwide, combined with the morbidity associated with conventional surgical treatment has led to the development and use of alternative minimally invasive non-surgical treatments. Biopsy and pathology are used to guide BCC diagnosis and assess margins and subtypes, which then guide the decision and choice of surgical or non-surgical treatment. However, alternatively, a noninvasive optical approach based on combined reflectance confocal microscopy (RCM) and optical coherence tomography (OCT) imaging may be used. Optical imaging may be used to guide diagnosis and margin assessment at the bedside, and potentially facilitate non-surgical management, along with long-term monitoring of treatment response. Noninvasive imaging may also complement minimally invasive treatments and help further reduce morbidity. In this paper, we highlight the current state of an integrated RCM/OCT imaging approach for diagnosis and triage of BCCs, as well as for assessing margins, which therefore may be ultimately used for guiding therapy.
Citation
Iftimia N, Sahu A, Cordova M, Maguluri G, Gill M, Alessi-Fox C, Gonzalez S, Navarrete-Dechent C, Marghoob A, Chen CJ, Rajadhyaksha M. The potential utility of integrated reflectance confocal microscopy-optical coherence tomography for guiding triage and therapy of basal cell carcinomas. J Cancer. 2020 Aug 18;11(20):6019-6024. doi: 10.7150/jca.47026. PMID: 32922542; PMCID: PMC7477415.