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Comparison of a chemiluminometric immunoassay with culture for diagnosis of chlamydial infections in infants.
Journal Title
Journal of clinical microbiology
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1992-07
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30
Publication Issue
7
Publication Begin
1867
Publication End
9
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Abstract
The performance of Magic Lite (CIBA-Corning), a chemiluminescent immunoassay (CIA), was compared with that of culture for the diagnosis of neonatal chlamydial conjunctivitis and respiratory infection. We performed a retrospective evaluation of 51 ocular and 96 nasopharyngeal specimens previously collected for culture testing with the CIA. The sensitivities for the ocular and the nasopharyngeal specimens were 91 and 91.7%, respectively. The specificities for both sites were 100%. A subsequent prospective study evaluating 71 ocular and 38 nasopharyngeal specimens revealed sensitivities of 83.3 and 20%, respectively. The specificities for both sites were 100%. The CIA performed favorably, compared with culture, for the diagnosis of chlamydial conjunctivitis; however, the CIA appeared less sensitive for the diagnosis of respiratory infection, including pneumonia.
Citation
Dumornay W, Roblin PM, Gelling M, Hammerschlag MR, Worku M. Comparison of a chemiluminometric immunoassay with culture for diagnosis of chlamydial infections in infants. J Clin Microbiol. 1992 Jul;30(7):1867-9. doi: 10.1128/jcm.30.7.1867-1869.1992. PMID: 1629345; PMCID: PMC265395.