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The clinical significance of Raynaud's phenomenon in systemic lupus erythematosus.
Journal Title
Arthritis and rheumatism
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22
Publication Issue
8
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815
Publication End
9
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Abstract
In a prospective study of 226 patients with systemic lupus erythematosus (SLE), 91 patients (40%) had Raynaud's phenomenon. These patients were compared to 135 patients without Raynaud's phenomenon. Patients with Raynaud's phenomenon had a greater incidence of arthritis (P less than 0.02), malar rash (P less than 0.003), and photosensitivity (P less than 0.03), and a lesser incidence of severe renal disease as manifested by serum creatinine over 3.0 mg/dl (P less than 0.007) or creatinine clearance below 60 ml/minute. Patients with Raynaud's phenomenon were less likely to have severe, life threatening disease and received a lower average monthly (P less than 0.01) and a lower peak daily corticosteroid dose (P less than 0.01). Fourteen patients (16%) with Raynaud's phenomenon died, compared to 41 without (30%) (P less than 0.03). Raynaud's phenomenon in patients with SLE is associated with milder disease and may be regarded as a favorable prognostic sign.
Citation
Dimant J, Ginzler E, Schlesinger M, Sterba G, Diamond H, Kaplan D, Weiner M. The clinical significance of Raynaud's phenomenon in systemic lupus erythematosus. Arthritis Rheum. 1979 Aug;22(8):815-9. doi: 10.1002/art.1780220802. PMID: 465096.