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The SUNY Open Access Repository (SOAR) is a centrally managed online digital repository that stores, indexes, and makes available scholarly and creative works of SUNY faculty, students, and staff across SUNY campuses. SOAR serves as an open access platform for those SUNY campuses that do not have their own open access repository environments. 

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  • Factors Influencing Social and Community Participation of People with Spinal Cord Injury in Karnataka, India

    Babu, Heavenna; Sriraman, Sheetal; Karthikbabu, Suruliraj; Sophia, P.; Kumar, Senthil N. S. (Medknow, 2024-01-12)
    Background: Social and community participation are major indicators to assess the adequacy of treatment and rehabilitation in patients with spinal cord injury (SCI). This study examined the relationship between functional independence, level of disability, and social and community participation among people with SCI in India. Materials and method: In this cross sectional study, 110 persons with SCI, aged 18 years and above participated in a community setting, in Karnataka, India. Spinal Cord Independence Measure Version III-self-reporting (SCIM III-SR), Craig Handicap Assessment and Reporting Technique (CHART), and WHO Disability Assessment Schedule 2.0 (WHODAS) were the clinical outcome measures. Spearman's correlation and stepwise multiple linear regression were done to determine association and identify the factors determining the community participation of people with SCI. Results: CHART physical independence had a positive correlation with SCIM self-care (R = 0.446) and SCIM mobility (r = 0.434). CHART cognitive independence (R = -0.38) and CHART mobility (R = -0.396) had a weak correlation with WHODAS. SCIM self-care and SCIM mobility (R2 = 0.34) were determinants of CHART cognitive independence. SCIM respiratory and sphincter management and SCIM self-care (R2 = 0.327) were determinants of CHART mobility. Conclusion: Self-care and mobility of people with SCI determine their ability to successfully reintegrate into the community, warranting a comprehensive community rehabilitation program.
  • The New Urology Match: How Recent Innovations Including Virtual Interviews and Preference Signaling Have Changed Match Outcomes

    Heard, John; Rawal, Rushil Y; Amazan, Bradley; Jeune, Karl-Ray; Freedman, Andrew (Springer Science and Business Media LLC, 2024-01-29)
    Objectives: To determine how recent changes in the urology match occurring from 2021 to 2023, including virtual interviews (VIs) and preference signals (PS), affected match outcomes. Methods: The American Urological Association (AUA) match data from 2021 to 2023 was compared to the 15 years prior. This was obtained from the AUA website and a previous study of public AUA match data. Self-reported applicant characteristics and outcomes from the Urology Residency Applicant Spreadsheet 2021-2023 were compared to the four years prior. Results: Between 2021 and 2023, residency programs offered 43 interviews each, compared to an average of 35 in the 15 years prior. Programs have been receiving more applications each year, from a low of 225 in 2019 to a peak of 347 in 2022. This resulted in an interview offer rate of 13% between 2021 and 2023, compared to 16% in the five years prior. Applicants applied to a mean of 88 programs in 2023, increasing each year since 40 in 2006. Applicants attended 12 interviews on average between 2021 and 2023, compared to 13 in the two years prior. Self-reported applicant data similarly demonstrated that, compared to the four years prior, applicants between 2021 and 2023 applied to more programs (81 vs. 70), had a lower interview offer rate (22% vs. 32%), and a higher interview acceptance rate (90% vs. 75%). Conclusions: During the years with VIs, programs offered more interviews and applicants attended fewer on average, indicating a larger applicant pool was interviewed. Despite the introduction of PS, applicants applied to more programs in 2022 and 2023 than ever before.
  • Gender and disease-inclusive nomenclature consolidation of theragnostic target, prostate-specific membrane antigen (PSMA) to folate hydrolase-1 (FOLH1)

    Ramirez-Fort, Marigdalia K.; Gilman, Casey K.; Alexander, Jacob S.; Meier-Schiesser, Barbara; Gower, Arjan; Olyaie, Mojtaba; Vaidya, Neel; Vahidi, Kiarash; Li, Yuxin; Lange, Christopher S.; et al. (Frontiers Media SA, 2024-02-09)
  • IPSC-derived neurons as a model for studying the role of RELN in autism

    Mohktari, Ryan (2024-03-11)
    RELN is strongly associated with Autism Spectrum Disorder (ASD). Homozygous loss of the encoded protein REELIN is associated with severe neurodevelopmental phenotypes characterized by lissencephaly and cerebellar hypoplasia, yet the ASD linked variants are typically heterozygous and appear to require additional genetic risk to cause ASD. To functionally characterize a RELN variant in a patient with ASD, we used induced pluripotent stem cells (iPSCs) from a family of non-autistic parents and their son who had ASD (the proband). The proband has a maternally-inherited missense variant (R2457C) in the RXR motif of the REELIN protein. We differentiated the iPSCs into two types of neurons, inhibitory neurons which model the inhibitory forebrain neurons that secrete REELIN, and excitatory neurons which model the cortical pyramidal neurons that respond to REELIN. Immunoblotting revealed that the proband inhibitory neurons had a lower ratio of extracellular/intracellular REELIN compared to that of the parental neurons, suggesting a decreased REELIN secretion. Sholl analysis on the proband excitatory neurons showed reduced dendritic complexity and reduced total length compared to the parental neurons. REELIN treatment increased the dendritic length and complexity in proband neurons up to the level of parental neurons. CRISPR/Cas9-mediated RELN KO did not change the dendritic phenotype in the excitatory neurons, ruling out a cell autonomous role for REELIN in these neurons. The proband excitatory neurons also had lower mRNA expression of WNT target genes in response to WNT3a, suggesting an underactive WNT signaling, as well as higher total GSK3β protein and lower phosphorylation at the inhibitory S9 site, indicating an overactive GSK3β signaling. Inhibition of GSK3β improved the proband neurons dendritic complexity in the proximal parts of the dendritic arbor. However, inhibition of mTOR signaling, which has shown to regulate REELIN signaling, did not change the dendritic morphology. In conclusion, the pathophysiology of ASD in the proband likely consists of a reduced REELIN secretion from the inhibitory neurons and an additional vulnerability in the REELIN-responding excitatory neurons, the latter likely being an overactive GSK3β and an underactive WNT signaling, all of which result in reduced dendritic complexity.
  • Una Antígona para tiempos de supervivencia: lo heroico y lo sucio en Antígona del dramaturgo cubano Yerandy Fleites

    Rojo, Roseli (University of Kansas Libraries, 2023-05-01)
    This essay analyzes Antígona (2008) by Yerandy Fleites to show how the author tackles the current Cuban political situation by rewriting the Sophoclean tragedy. Fleites adjusts the Greek myth to the Cuban context by means of parody and an intertextual dialogue with both Jean Anouilh’s Antígona (1944) and Peruvian poet José Watanabe’s Antígona (2000). The study then unpacks the idea of dirtiness and Fleites’ depiction of the female heroine to demonstrate how the dramatist proposes hybris as the main psychological driver behind the Cuban Antigone (and that, to an extent, of the generation she represents) to suggest possible avenues for sociopolitical change. At the same time, this study considers the interpretations of Fleites’ Antígona that Cuban directors Pedro Franco and Julio César Ramírez respectively brought to the stage in 2013 and 2020. Ramírez’s reading in particular provides an understanding of Antígona in the context of the protests that occurred on November 27, 2020, when intellectuals, writers, and artists demanded that the Cuban Ministry of Culture recognize their rights and their freedom as citizens.

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