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The SUNY Open Access Repository (SOAR) is a centrally managed online digital repository that stores, indexes, and makes available scholarly and creative works of SUNY faculty, students, and staff across SUNY campuses. SOAR serves as an open access platform for those SUNY campuses that do not have their own open access repository environments. 

Access to SUNY campus communities in SOAR are available below under SUNY sectors and also listed alphabetically under the Campus Communities in SOAR on the navigation bar on the left.

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  • MFA Thesis - Painting

    Byrd, Kevin (2024-05)
    Through My paintings I create commentary that addresses issues of race, power dynamics, and identity, which would serve as a catalyst for important conversations about societal challenges and the need for representation in visual culture. My research into the African American cultural and historical context, plays a crucial role in my studio practice.
  • The murine absolute visual threshold: behavior & retinal pathways

    LaMagna, Sam (2024-05-17)
    Connexin 36 (Cx36) gap junctions are important for governing the sensitivity of the dark-adapted retina. Despite its importance for physiological sensitivity, the degree to which retinal Cx36 governs the psychophysical absolute threshold is not known. The purpose of this work is to study to what extent inner- and outer-retinal Cx36 governs the absolute visual threshold. In Chapter 2 we developed a one-alternative forced choice (1AFC) task for measuring murine absolute visual thresholds to full-field flash stimuli. We found that our 1AFC task, in conjunction with the theory of signal detection, gave response bias-independent absolute visual threshold estimated. Using this assay, we found that decision criteria are related to response times. In Chapter 3 we used the 1AFC task and the power of transgenic mice to assess the relative contributions of inner and outer retinal Cx36 to the absolute visual threshold. We concluded that inner, not outer, retinal Cx36 is most responsible for governing the absolute visual threshold. In parallel, by testing mice with disrupted rod vision, we determined that rod OFF pathways, and not cones, set the absolute visual threshold in the absence of Cx36. Finally, we studied the impact of Cx36 on temporal summation at absolute threshold, by obtaining thresholds for a range of flash durations. Threshold-vs-duration data was then fit with a model of temporal summation that allowed us to determine whether Cx36 influences the temporal filtering properties of scotopic vision. Our model fits suggest that photoreceptor Cx36 may play a role in temporal processing at absolute visual threshold. Overall, this work sheds new light on the behavioral dynamics and neural underpinnings of rod mediated vision.
  • Battle of arms: human cytomegalovirus manipulates monocyte survival for viral dissemination.

    Geiler, Brittany (2024-05-16)
    Human cytomegalovirus (HCMV) is a highly prevalent pathogen with seropositivity rates reaching upwards of 90% in the United States. Most primary infections are asymptomatic in immunocompetent individuals, but HCMV poses a significant risk in immunocompromised and immunonaїve individuals including transplant patients and developing fetuses in utero. The key to systemic dissemination of HCMV relies upon the infection of monocytes, which function as non-permissive vehicles to deliver virus to end organ tissues. These primary infected monocytes also travel to the bone marrow, infecting CD34+ stem cells, leading to the establishment of a lifelong HCMV infection. HCMV can reactivate at any point throughout the host's lifetime, leading to HCMV-infected stem cells exiting the bone marrow as monocytes, disseminating to end-organ tissue, and perpetuating HCMV disease. In circulation, monocytes have a short life span of 48 hours that can be accelerated by the cellular death pathway, apoptosis, as a cellular defense mechanism against viral infection. Our lab has shown during primary infection, HCMV circumvents intrinsic apoptotic pathways, however, the mechanism by which HCMV blocks extrinsic apoptosis is unclear. The studies in this thesis reveal that HCMV induces cFLIP expression, inhibiting extrinsic apoptosis effector caspase 8. This effective inhibition of intrinsic and extrinsic apoptosis prompts trap-door death pathway necroptosis. However, the mechanism in which this pathway is activated and how HCMV modulates this pathway to promote cell survival is unknown. In these works, we identified TLR3 as the death receptor responsible for inducing necroptosis. To circumvent this activation, HCMV upregulates autophagy, a ubiquitous cellular recycling process. We saw the inhibition of autophagy altered nucleocytoplasmic shuttling and activation of executioner kinase, MLKL, culminating in necrotic cell death. This work highlights the delicate balance between pro-survival and pro-death elements in HCMV infected monocytes. However, investigating how HCMV modulates cellular death pathways in a primary infection monocyte model does not fully encapsulate the role of monocytes in HCMV dissemination. Once HCMV latency is established in CD34+ stem cells, this allows HCMV the ability to persist in the host for their entire life span as monocytes derived from latently infected stem cells that can re-seed HCMV to peripheral organs to establish a chronic lytic infection. To investigate this understudied secondary population of HCMV-infected monocytes, we developed a model in which primary HCMV-infected monocytes and infected monocytes derived from latently infected stem cells are on the same genetic background by differentiating a CD34+ myeloblastic cell line. Though preliminary, we believe that this model, combined with investigations of mechanisms in which HCMV promotes survival in primary infected monocytes, will allow for the development of novel therapies that specifically target HCMV-infected monocytes, thus preventing viral dissemination and the establishment of disease.
  • Emerging Technologies Supporting Cognitive Development In School-Age Children

    Bucci, Joanne (SUNY Polytechnic Institute, 2023-12)
    Over the past few years, the importance of mental health has gained unprecedented attention and priority across various sectors of society. Many children have dealt with some form of undiagnosed or untreated mental illness that interferes with their ability to learn. These disorders can seriously affect daily life and continue into adulthood, creating a precarious home, school, and social life. Due to the increased use of technology over the 2020 Covid-19 pandemic, it is now commonplace to rely on technological innovations for mental health in children. Technology has advanced to expand child engagement and interactivity, especially for children who struggle with emotional regulation, social skills, and coping strategies. Research has shown that the human brain is fully developed at age 25. The longer a child has cognitive and emotional stability, the greater it positively affects their lives. Interventions should be given early in the child’s life. And if technology is available to aid in those interventions, everyone should be able to access them. The main objective of this paper is to explore how emerging digital interventions can improve mental health in children, specifically those with deficits in cognitive development. In conjunction with this paper, the website childmindtechnologies.com has been created for practitioners, educators, and parents, aiming to facilitate the adoption of these digital interventions in various settings, whether it be at home, in school, or in clinical environments.
  • Harnessing AI for Holistic Educational Development: Designing a Comprehensive Course

    Popov, Ivan D. (SUNY Polytechnic Institute, 2023-12)
    This paper outlines the project, methods, and theoretical analysis undertaken to address the question: How can a curriculum be optimized to effectively prepare contemporary students for a professional career in graphic design? Can AI be used to build this course and make it effective, if restricted to its use as a sounding board and source of inspiration, allowing access and collaboration with the world's information and innovative teaching methods? The theoretical background reveals that the traditional lecture model is increasingly being overshadowed by holistic and hands-on approaches, and that, furthermore, it is essential to educate students about potential career paths beyond their immediate field of study. The conclusion is drawn that by integrating modern pedagogies, career development practices, and the latest technological advances in design, a curriculum can be developed that resonates with students, laying a robust foundation for their academic and professional trajectories. This paper concludes that while there are studies that address individual components of the project outcome, this comprehensive and integrative approach, assisted with the use of artificial intelligence tools, appears to be a novel contribution to the field.

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